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Arbeitskreis Schlitzer

Prof. Dr. M. Schlitzer

 

Mitarbeiter

 

ehemalige Mitarbeiter

 

Arbeitsgebiete

 

ausgewählte Publikationen

 

Mitarbeiter gesucht

 

Praktikum 3.Semester

 

Arzneistoffvorlesung

 

 

Ausgewählte Publikationen:

 

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wählen Sie einfach hier:

 

 

2000

  • M. Schlitzer, I. Sattler, A. Friese, I. Zündorf, T. Dingermann, Synthesis of 4-(Acylaminomethyl)-benzamides and their Evaluation as Potential Anti-Cancer, Agents Anticancer Res. 2000, 20, 1723-1726.

  • M. Schlitzer, M. Böhm, I. Sattler, H.-M. Dahse, Design, Synthesis and Early Structure-Activity Relationship of Farnesyltransferase Inhibitors which Mimic Both the Peptidic and the Prenylic Substrate, Bioorg. Med. Chem. 2000, 8, 1991-2006.

  • M. Schlitzer, M. Böhm, I. Sattler, Non-Peptidic, Non-Prenylic Bisubstrate Farnesyltransferase Inhibitors 3. Structural Requirements of the Central Moiety for Farnesyltransferase Inhibitory Activity, Bioorg. Med. Chem. 2000, 8,
    2399- 2406.


  • M. Schlitzer, I. Sattler, Non-Peptidic, Non-Prenylic Bisubstrate Farnesyltransferase Inhibitors 4. Effect on Farnesyltransferase Inhibitory Activity of Conformational Restrictions in the Central Group, Pharm. Pharmacol. Commun. 2000, 5, 117-124.

  • M. Schlitzer, I. Sattler, Non-Peptidic, Non-Prenylic Bisubstrate Farnesyltransferase Inhibitors 5. Effect on Farnesyltransferase Inhibitory Activity of a Carboxyl Group at the Central Group, Pharm. Pharmacol. Commun. 2000, 5, 507-512.

  • M. Schlitzer, I. Sattler, Non-Thiol Farnesyltransferase Inhibitors: the concept of benzophenone-based bisubstrate analog farnesyltransferase inhibitors, Eur. J. Med. Chem. 2000, 35, 721-726.

  • M. Schlitzer, H.-M. Dahse, Structure Activity Relationship of Antiproliferative N-Acyl-ß-Alanine Amides, Anticancer Res. 2000, 20, 4431-4434.

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2001

  • P. Wißner, H.-M. Dahse, M. Schlitzer, Structure activity relationship of antiproliferative N-acyl-aspartic acid dimethyl ester. 2. Variation of the aspartyl moiety, Die Pharmazie 2001, 56, 33-35.

  • M. Schlitzer, L. Rodriguez, P. F. Kador, Synthesis of Potential Aldose Reductase Inhibitors Based on Minimal Pharmacophore Requirements, Pharm. Pharmacol. 2001, 53, 831 - 839.

  • M. Schlitzer, A. Winter-Vann, P. J. Casey, Non-Peptidic, Non-Prenylic Inhibitors of the Prenyl Protein-Specific Protease Rce1, Bioorg. Med. Chem. Lett. 2001, 11, 425-427.

  • A. Mitsch, P. Wißner, I. Sattler, M. Schlitzer, Non-Thiol Farnesyltransferase Inhibitors: Structure-Activity Relationships of Aralkylsubsituted Benzophenones, Arch. Pharm. Pharm. Med. Chem. 2001, 334, 40-44.

  • J. Wiesner, P. Wißner, H.-M. Dahse, H. Jomaa, M. Schlitzer, Discovery of a Novel Lead Structure for Anti-Malarials, Bioorg. Med. Chem. 2001, 9, 785-792.

  • J. Wiesner, A. Mitsch, P. Wißner, H. Jomaa, M. Schlitzer, Structure-activity relationships of novel anti-malarial agents: 1. arylacyl and cyclohexylacyl derivatives of 5-amino-2-tolylacetylaminobenzophenone, Die Pharmazie 2001, 56, 443-444.

  • J. Wiesner, A. Mitsch, P. Wißner, H. Jomaa, M. Schlitzer, Structure-Activity Relationships of Novel Anti-Malarial Agents: 2. Cinnamic Acid Derivatives, Bioorg. Med. Chem. Lett., 2001, 11, 423-424.

  • A. Reichenberg, J. Wiesner, C. Weidemeyer, E. Dreiseidler, S. Sanderbrand, B. Altincicek, E. Beck, M. Schlitzer, H. Jomaa, Diaryl Ester Prodrugs of FR900098 with Improved in-vivo Antimalarial Activity, Bioorg. Med. Chem. Lett.
    2001
    , 11, 833-835.


  • J. Sakowski, M. Böhm, I. Sattler, H.-M. Dahse, M. Schlitzer, Synthesis, Molecular Modeling and Structure Activity Relationship of Benzophenone-Based CAAX-Peptidomimetic Farnesyltransferase Inhibitors, J. Med. Chem. 2001, 44, 2886-2899.

  • M. Böhm, A. Mitsch, P. Wißner, I. Sattler, M. Schlitzer, Exploration of Novel Aryl Binding Sites of Farnesyltransferase Using Molecular Modeling and Benzophenone-Based Farnesyltransferase Inhibitors, J. Med. Chem. 2001, 44, 3117-3124.

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2002

  • J. Sakowski, I. Sattler, M. Schlitzer, Non-Thiol Farnesyltransferase Inhibitors: N-(4-Acylamino-3-benzoylphenyl)-4-nitrocinnamic Acid Amides, Bioorg. Med. Chem. 2002, 10, 233-239.

  • J. Sakowski, M. Böhm, I. Sattler, M. Schlitzer, Non-Thiol Farnesyltransferase Inhibitors: Evaluatiuon of Different AA(X)-Peptidomimetic Substructures in Combination with Arylic Cysteine Replacements, Arch. Pharm. Pharm. Med. Chem. 2002, 335, 135-142.

  • M. Schlitzer, M. Böhm, I. Sattler, Non-Thiol Farnesyltransferase Inhibitors: Structure-Activity Relationships of Benzophenone-Based Bisubstrate Analog Farnesyltransferase Inhibitors, Bioorg. Med. Chem. 2002, 10, 615-620.

  • J. Wiesner, K. Kettler, H. Jomaa, M. Schlitzer, Structure-Activity Relationships of Novel Anti-Malarial Agents: 3. N-(4-Acylamino-3-benzoylphenyl)-4-propoxycinnamic Acid Amides, Bioorg. Med. Chem. Lett. 2002, 12, 543-545.

  • A. Mitsch, M. Böhm, P. Wißner, I. Sattler, M. Schlitzer, Non-Thiol Farnesyltransferase Inhibitors: Utilization of an Aryl Binding Site by 5-Arylacryloylaminobenzophenones, Bioorg. Med. Chem. 2002, 10, 2657-2662.

  • M. Schlitzer, Structure Based Design of Benzophenone-Based Non-Thiol Farnesyltransferase Inhibitors, Curr. Pharm. Design 2002, 8, 1713-1722.

  • J. Wiesner, A. Mitsch, P. Wißner, O. Krämer, H. Jomaa, M. Schlitzer, Structure-Activity Relationships of Noval Anti-Malaria Agents. Part 4: N-(3-Benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic Acid Amides, Bioorg. Med. Chem. Lett. 2002, 12, 2681-2683.

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2003

  • J. Wiesner, K. Kettler, J. Sakowski, R. Ortmann, H. Jomaa, M. Schlitzer, Structure-Activity Relationships of Novel Anti-Malarial Agents: 5. N-(4-Acylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic Acid Amides, Bioorg. Med. Chem. Lett. 2003, 13, 361-363.

  • J. Wiesner, R. Ortmann, A. Mitsch, P. Wißner, I. Sattler, H. Jomaa, M. Schlitzer, Farnesyltransferase-Inhibitors:
    5-Arylacryloylaminobenzophenones show Anti-Malarial Activity, Die Pharmazie 2003, 58, 289-290.

  • A. Mitsch, S. Bergmann, R. Gust, I. Sattler, M. Schlitzer, Non-Thiol Farnesyltransferase Inhibitors: FTase-Inhibition and Cellular Activity of Benzophenone-based Bisubstrate Analogue Farnesyltransferase Inhibitors, Arch. Pharm. Pharm. Med. Chem. 2003, 336, 242-250.

  • J. Wiesner, K. Fucik, K. Kettler, J. Sakowski, R. Ortmann, H. Jomaa, M. Schlitzer, Structure-Activity Relationships of Novel Anti-Malarial Agents: 6. N-(4-Arylpropionylamino-3-benzoylphenyl)-[5-(4-nitrophenyl)-2-furyl]acrylic Acid Amides, Bioorg. Med. Chem. Lett. 2003, 13, 1539-1541.

  • J. Wiesner, A. Mitsch, H. Jomaa, M. Schlitzer, Structure-Activity Relationships of Novel Anti-Malarial Agents: 7. N -(3-Benzoyl-4-tolylacetylaminophenyl)-3-(5-aryl-2-furyl)acrylic Acid Amides with Polar Moieties, Bioorg. Med. Chem. Lett. 2003, 13, 2159-2161.

  • R. Ortmann, J. Wiesner, A. Reichenberg, D. Henschker, E. Beck, H. Jomaa, M. Schlitzer, Acyloxyalkyl Ester Prodrugs of FR900098 with improved in vivo Antimalarial Activity, Bioorg. Med. Chem. Lett. 2003, 13, 2163-2166.

  • J. Wiesner, R. Ortmann, H. Jomaa, M. Schlitzer, Neue Antimalaria-Wirkstoffe, Angewandte Chemie 2003 , 115 , 5432-5451; und Angewandte Chemie Int. Ed. 2003 , 42 , 5274-5293.

  • J. Wiesner, A. Mitsch, M. Altenkämper, R. Ortmann, H. Jomaa, M. Schlitzer, Structure-Activity Relationships of Novel Anti-Malarial Agents: 8. Effect of Different Central Aryls in Biarylacryloylaminobenzophenones on Antimalarial Activity, Die Pharmazie 2003, 58, 854 – 856.

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2004

  • J. Wiesner, K. Kettler, J. Sakowski, R. Ortmann, A. M. Katzin, E. A. Kimura, K. Silber, G. Klebe, H. Jomaa, M. Schlitzer, Farnesyltransferase-Inhibitoren hemmen das Wachstum von Malaria-Erregern in vitro und in vivo, Angewandte Chemie 2004 , 116 , 254 - 257; Angewandte Chemie Int. Ed. 2004, 43, 251 - 254.

  • A. Mitsch, M. Böhm, I. Sattler, M. Schlitzer, Non-thiol farnesyltransferase inhibitors: utilization of the near aryl binding site by 5-arylacetylaminobenzophenones, Arch. Pharm. (Weinheim), 2004, 337, 213-218.

  • A. Mitsch, P. Wissner, M. Böhm, K. Silber, G. Klebe, I. Sattler, M. Schlitzer, Non-thiol farnesyltransferase inhibitors: utilization of the far aryl binding site by 5-cinnamoylaminobenzophenones, Arch Pharm (Weinheim), 2004, 337,
    493-501.

  • A. Mitsch, P. Wissner, K. Silber, P. Haebel, I. Sattler, G. Klebe, M. Schlitzer, Non-thiol farnesyltransferase inhibitors: N-(4-tolylacetylamino-3-benzoylphenyl)-3-arylfurylacrylic acid amides, Bioorg Med Chem, 2004, 12, 4585-4600.

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2005

  • M. I. Esteva, K. Kettler, C. Maidana, L. Fichera, A. M. Ruiz, E. J. Bontempi, B. Andersson, H. M. Dahse, P. Haebel, R. Ortmann, G. Klebe, M. Schlitzer, Benzophenone-based farnesyltransferase inhibitors with high activity against Trypanosoma cruzi, J Med Chem, 2005, 48, 7186-7191.

  • K. Kettler, J. Sakowski, J. Wiesner, R. Ortmann, H. Jomaa, M. Schlitzer, Novel lead structures for antimalarial farnesyltransferase inhibitors, Pharmazie, 2005, 60, 323-327.

  • K. Kettler, J. Wiesner, K. Fucik, J. Sakowski, R. Ortmann, H. M. Dahse, H. Jomaa, M. Schlitzer, 2-(aminoacylamino)-benzophenones: farnesyltransferase inhibition and antimalarial activity, Pharmazie, 2005, 60, 677-682.

  • K. Kettler, J. Wiesner, K. Silber, P. Haebel, R. Ortmann, I. Sattler, H. M. Dahse, H. Jomaa, G. Klebe, M. Schlitzer, Non-thiol farnesyltransferase inhibitors: N-(4-aminoacylamino-3-benzoylphenyl)-3-[5-(4-nitrophenyl)-2 furyl]acrylic acid amides and their antimalarial activity, Eur J Med Chem, 2005, 40, 93-101.

  • A. Mitsch, M. Altenkämper, I. Sattler, M. Schlitzer, Non-thiol farnesyltransferase inhibitors: utilization of the far aryl binding site by arylthienylacryloylaminobenzophenones, Arch Pharm (Weinheim), 2005, 338, 9-17.

  • R. Ortmann, J. Wiesner, A. Reichenberg, D. Henschker, E. Beck, H. Jomaa, M. Schlitzer, Alkoxycarbonyloxyethyl ester prodrugs of FR900098 with improved in vivo antimalarial activity, Arch Pharm (Weinheim), 2005, 338, 305.

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2006

  • K. Kettler, J. Wiesner, R. Ortmann, H. M. Dahse, H. Jomaa, M. Schlitzer, Antimalarial activity of methylpiperazinyl-substituted benzophenone-based farnesyltransferase inhibitors, Pharmazie, 2006, 61, 63-65.

  • M. Schlitzer, Selektiver Enzyminhibitor statt ldquoIron-triggered cluster bombrdquo. Neue Erkenntnisse zum Wirkmechanismus von Artemisininderivaten, Pharm Unserer Zeit, 2006, 35, 8-9.

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2007

  • R. Ortmann, J. Wiesner, K. Silber, G. Klebe, H. Jomaa, M. Schlitzer, Novel deoxyxylulosephosphate-reductoisomerase inhibitors: fosmidomycin derivatives with spacious acyl residues, Arch Pharm (Weinheim), 2007, 340, 483-490.

  • M. Schlitzer, Malaria chemotherapeutics part I: History of antimalarial drug development, currently used therapeutics, and drugs in clinical development, ChemMedChem, 2007, 2, 944-986.

  • J. Wiesner, R. Ortmann, H. Jomaa, M. Schlitzer, Double ester prodrugs of FR900098 display enhanced in-vitro antimalarial activity, Arch Pharm (Weinheim), 2007, 340, 667-669.

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2008

  • D. Barthel, M. Schlitzer, G. Pradel, Telithromycin and quinupristin-dalfopristin induce delayed death in Plasmodium falciparum, Antimicrob Agents Chemother, 2008, 52, 774-777.

  • T. Haemers, J. Wiesner, D. Giessmann, T. Verbrugghen, U. Hillaert, R. Ortmann, H. Jomaa, A. Link, M. Schlitzer, S. Van Calenbergh, Synthesis of beta- and gamma-oxa isosteres of fosmidomycin and FR900098 as antimalarial candidates, Bioorg Med Chem, 2008, 16, 3361-3371.

  • K. Kohring, J. Wiesner, M. Altenkämper, J. Sakowski, K. Silber, A. Hillebrecht, P. Haebel, H. M. Dahse, R. Ortmann, H. Jomaa, G. Klebe, M. Schlitzer, Development of benzophenone-based farnesyltransferase inhibitors as novel antimalarials, ChemMedChem, 2008, 3, 1217-1231.

  • J. Perruchon, R. Ortmann, M. Altenkämper, K. Silber, J. Wiesner, H. Jomaa, G. Klebe, M. Schlitzer,Studies addressing the importance of charge in the binding of fosmidomycin-like molecules to deoxyxylulosephosphate reductoisomerase, ChemMedChem, 2008, 3, 1232-41.

  • M. Schlitzer, Antimalarial drugs - what is in use and what is in the pipeline, Arch Pharm (Weinheim), 2008, 341, 149.

  • J. Wiesner, A. Reichenberg, S. Heinrich, M. Schlitzer, H. Jomaa, The plastid-like organelle of apicomplexan parasites as drug target, Curr Pharm Des, 2008, 14, 855-871.

  • M. Altenkämper, M. Schlitzer, Repellentien und Insektizide - Erfolgreich gegen den Insekten-Angriff,
    Pharmazeutische Zeitung, 2008, 153, 18-25.

  • A. Stich, M. Altenkämper, M. Schlitzer, Malaria - Teil I: Medikamentöse Therapie, Deutsche Apotheker Zeitung, 2008, 148, 36-45.

  • A. Stich, M. Altenkämper, M. Schlitzer, Malaria - Teil II: Prophylaxe, Deutsche Apotheker Zeitung, 2008, 148, 53-58.

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